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KMID : 0861020230380050001
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Korea Journal of Herbology
2023 Volume.38 No. 5 p.1 ~ p.7
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Comparison of skin damage recovery between natural and cultivated Angelicae Gigantis Radix
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Hwang Sun-Young
Lee Mee-Hyun
Wi Kwan-Hwan
Kim Do-Hyun
Lee Soong-In
Jeong Jong-Gil
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Abstract
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Purpose : To compare the skin damage recovery efficacy of natural Angelicae Gigantis Radix extract (N-AGR) and cultivated A. Gigantis Radix extract (C-AGR). Through this, we confirmed whether the quality standards of herbal medicines recorded in the classic books make a difference in the experimental efficacy using epithelial cells.
Methods : The quality standards of medicinal herbs in the classic books and the cultivation and processing conditions of two types of A. gigas were compared. After inducing oxidative stress with H2O2, cytoprotective property of N-AGR and C-AGR were evaluated through cell viability. Additionally, after wound formation of epithelial JB6 cells, N-AGR and C-AGR were treated to evaluate wound healing efficacy.
Result : The natural A, gigas met the excellent quality standards of the classic books. N-AGR inhibited cell death by oxidative stress induced by H2O2, and was superior to C-AGR. Both N-AGR and C-AGR showed dose-dependent wound healing efficacy, but N-AGR was significantly superior to C-AGR.
Conclusions : Through the oxidative stress of skin and skin wound healing efficacy experiments using epithelial cells, natural A. gigas showed superior efficacy compared to cultivated A. gigas.
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KEYWORD
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Angelica gigas, Angelicae Gigantis Radix, natural, wild, skin, epithelial cell, oxidative stress, wound healing
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